The half-life of Ambien, or the time it takes the substance to be eliminated from your bloodstream, is approximately 2-3 hours for the immediate … Half-life: 2.5–2.6 hours. Ambien Interactions. Interactions. Concomitant other sedative-hypnotics including other zolpidem products: not recommended. How Long Does Ambien Last? Ambien has a short half-life of about 2.5 hours in healthy adults, which means it\’s out of your system relatively quickly. If you … The half-life of Ambien is 2 hours. Generally it is considered that it takes 5.5 x half-life for a drug to be removed from the body, in that it … Dosage adjustments of. AMBIEN and of other concomitant CNS depressants may be necessary when AMBIEN is … half-life. (17%) was observed. There was no evidence of … Ambien has a short half-life of about 2 hours, meaning that it is metabolized quickly. At slightly higher doses, it is detectable in blood for approximately 11 …